Biostimulation has become a key approach in regenerative aesthetic medicine, aiming to activate collagen production and improve tissue quality. However, clinical responses vary significantly, suggesting that successful regeneration depends not only on the chosen treatment but also on the biological capacity of the tissue to respond.

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Ageing skin is not only characterised by structural decline but also by reduced biological responsiveness. A “tired tissue state” may demonstrate decreased cellular activity, impaired extracellular matrix organisation, altered hydration, low-grade inflammation, and reduced regenerative potential — which is why the clinical question should shift from which stimulation to use, to whether the tissue has the capacity to respond at all.

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This session introduces tissue readiness as an essential factor in achieving predictable outcomes, covering how to assess skin quality, hydration and barrier function, inflammation and oxidative stress, and regenerative potential and patient-related factors — helping clinicians move towards more personalised, consistent and long-lasting regenerative outcomes.